Floating table by Ingo Maurer for Established & Sons

Milan 2013: German designer Ingo Maurer’s table without any legs has gone into production with British brand Established & Sons.

Floating table by Ingo Maurer for Established & Sons

The white table top appears to float at first glance, but is in fact supported on an extended arm from each of the four black chairs.

Floating table by Ingo Maurer for Established & Sons

Ingo Maurer devised a hidden mechanism beneath the table that allows the chairs to be pulled out so users can sit down. Rectangular and circular surfaces are available.

Floating table by Ingo Maurer for Established & Sons

The wooden table was first conceived in 2012 and has since been put into production with Established & Sons. The furniture was shown at Ventura Lambrate in Milan last month.

Floating table by Ingo Maurer for Established & Sons

We’ve recently featured a coffee table by Foster + Partners made from a stretched metal disk and a shape-shifting table that transforms from a square to a triangle.

See more table designs »
See more design by Ingo Maurer »
See all our coverage of Milan 2013 »

Here is some extra information from Established & Sons:


This innovative piece is the first production table from the widely celebrated designer, Ingo Maurer. On first inspection, it appears to be archetypal wooden kitchen table and chairs but on closer viewing the table is revealed as ‘floating’; without any legs, supported by a simple extending mechanism which connects the chairs. Maurer has drawn inspiration from magic, ethereal substance and weightlessness. Floating Table invites the user to look more carefully at their simple daily objects and furniture for elements of surprise.

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JDS Architects reveals green office complex for Istanbul

News: JDS Architects has unveiled plans for an M-shaped office building with green terraces in the north of Turkey’s largest city.

Called Premier Campus Office, the building will be located in the Kagithane district of Istanbul.

JDS Architects reveals green office complex for Istanbul

Julien De Smedt Architects has proposed a gently curving M-shaped plan topped with several levels of green terraces.

As well as offices, the building will offer shops and leisure activities on its ground floor.

JDS Architects reveals green office complex for Istanbul

“We’ve thought of a building where inside interacts with outside, where the plan is flexible to allow for anyone to find its desired space and place, whether it be a small one man show company or a large corporate office employing hundreds,” the architects said.

The firm, which is based in Oslo, Copenhagen and Brussels, was selected from a shortlist that includes Dutch firm UNStudio and Italian architect Massimiliano Fuksas.

JDS Architects reveals green office complex for Istanbul

Construction on the building will begin in June.

The firm’s previous work includes a Danish housing development modelled on a cluster of icebergs and Holmenkollen ski jump in Oslo, Norway – see all architecture and design by JDS Architects.

JDS Architects reveals green office complex for Istanbul

Other projects in Turkey we’ve featured lately include an apartment building covered in timber louvres and shutters and plans for a museum at the site of the ancient city of Troy.

Here’s some more information from the architects:


The Premier Campus Office in Kagithane is a business district that focuses on the users working and living qualities and addresses its presence in Istanbul as a new form of contextual and urban approach: The building is formed by our desire to make it interact with its environment. It opens itself up to the neighbourhood and offers spaces to the users and the passers by such as plazas, intimate gardens and generous terraces.

The volume of the block is literally carved out to invite the surroundings in. The local hilly landscape, characteristic to Istanbul, is continued in the meandering of the volume both in plan, adapting to the site’s edges, and in section, weaving into itself in a series of gentle curving slopes, echoing the nearby Bosphorus waves. The vibrant commercial life of the ground floor burst out onto the plazas and the landscape. Upstairs the offices open out onto the green terraces, populated with lush vegetation, tempering the hot Springs and Summers. The volume reads clearly while still opening itself generously to the city from the far. As one gets closer the interiors become more discreet, protected by louvers that help shade from the sun.

The project acts as a catalyst of business life for a new Istanbul, that promotes contemporary culture, architecture and lifestyle. We’ve thought of a building where inside interacts with outside, where the plan is flexible to allow for anyone to find its desired space and place, whether it be a small one man show company or a large corporate office employing hundreds. We believe life is plural and various entities should coexist and exchange their experiences. The Premier Campus Office is where such a rich diversity can find its place.

Project: Commercial
Size: 100,000 sq m
Location: Istanbul, Turkey
JDS partner in charge: Julien De Smedt
Client: Feryapi
Team: DB Architects, Tavusbay-STATIK, Geodinamik, Dinamik Proje, Pozitif Proje
Project leader: Kamile Malinauskaite
Type: Invited competition
Status: Ongoing

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Job of the week: interior designer/architect at Gundry & Ducker

Job of the week!

Our job of the week on Dezeen Jobs is a position for an interior designer/architect with Gundry & Ducker in London, whose projects include the award-winning Dove House extension (shown above). See more stories about Gundry & Ducker on Dezeen here.

Visit the ad for full details or browse other architecture and design opportunities on Dezeen Jobs here. 

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“There’s a return to the commerce of the fair”

Dezeen and MINI World Tour: in the first of a series of films recorded at the MINI Paceman Garage in Milan last month, MINI head of design Anders Warming explains the thinking behind the brand’s presentation during the furniture fair while Johanna Agerman Ross, editor-in-chief of Disegno magazine, gives her opinion on the highlights of the world’s most important design week.

"There's a return to the commerce of the fair"
MINI head of design Anders Warming

“The MINI Paceman Garage is centred around how people act within a MINI community,” says Warming (above), explaining why the presentation – set up inside a car repair garage on Via Tortona – included features such as a record store, a coffee shop, a barber and a cinema. “They end up talking about anything that involves their life. And that’s why we have these different stations. It’s sort of like the extended life around the MINI.”

"There's a return to the commerce of the fair"
Dezeen’s studio in the MINI Paceman Garage

As part of our Dezeen and MINI World Tour, we set up a video studio within the garage, where we conducted interviews with some of the world’s leading design authorities to get their thoughts on the week.

"There's a return to the commerce of the fair"
Disegno editor-in-chief Johanna Agerman Ross

Agerman Ross of Disegno, our first interviewee, believes a key theme this year was the renewed focus on the official fair, the Salone Internazionale del Mobile, at the expense of the independent exhibitions that take place around the city.

"There's a return to the commerce of the fair"
Salone Internazionale del Mobile 2013

“I have found in the last few years that going to the city and going to the independent exhibitions have been where things have been really happening and interesting,”she says. “But I feel there’s a return to the reason why we’re all here – the commerce of the fair, the wheeling and dealing and the showing off of new products by the bigger brands.”

"There's a return to the commerce of the fair"
Furniture on display at the Salone Internazionale del Mobile 2013

“Milan this year was more subdued that previous years, with the ongoing economic crisis clearly affecting many companies. This has led to a more pared-back and business-like week without the frivolity of previous years,” says Agerman Ross.

“I think so. After all if the industry doesn’t work, the other things can’t happen either. There needs to be an economy and a network for these things to function. The designers and the brands need to make money in order to exist, and without a healthy commercial branch of design, the other things won’t exist either. One supports the other.”

"There's a return to the commerce of the fair"
Mattiazzi stand at the Salone Internazionale del Mobile 2013

“Everyone’s taking a step back, trying to be quite precise in what they’re putting out and trying to show products that seem quite close to hitting the market, rather than being just a product for show that won’t go into production,” she says. “It’s a tighter output altogether.”

See all our stories about Milan 2013.

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Scientists 3D-print bionic ear that hears beyond human range

3D-printed bionic ear

News: nanotechnology scientists at an American university have 3D-printed a bionic ear that can hear radio frequencies beyond a human’s normal range.

The ear is designed to integrate electronics with biology and create a flexible and fleshy alternative to mechanical prosthetics.

“This concept of 3D printing living cells together with electronic components and growing them into functional organs represents a new direction in merging electronics with biological systems,” said the scientists in their report, published in the journal Nano Letters.

The Princeton University team printed the ear from hydrogel – a material used as scaffolding in tissue engineering – using the commercially available Fab@Home 3D printer.

The hydrogel was infused with cells from a calf and intertwined with a polymer containing silver nanoparticles, which conduct radio frequencies.

The calf cells then matured into cartilage and hardened around a coil antenna, seen in the middle of the ear.

3D-printed bionic ear
A: CAD drawing of the ear; B: (top) optical
images of the functional materials (bottom) 3D printer; C: illustration of bionic ear

When tested, the bionic ear was found to receive signals across an extended frequency spectrum of 1 MHz to 5 GHz, far beyond the normal human range of 20 Hz to 20 KHz.

The team also created a complementary left ear and used a piece of music by Beethoven to successfully test the pair’s ability to hear in stereo.

At present the ear can only receive radio waves, but the scientists believe it would be possible to expand its hearing with other materials, such as pressure-sensitive sensors that register acoustic sounds.

Medical applications for 3D printing are becoming increasingly commonplace, as bioprinting expert Michael Renard recently told Dezeen in an interview for Print Shift, our one-off, print-on-demand magazine about this emerging technology.

“We’re working with small pieces of tissue at the moment – a small piece of blood vessel or liver,” he said. “Once you have the cells ready, we can print something in a few hours.” Read the full interview with Renard.

Other 3D printing projects we’ve reported on lately include prototypes of 3D-printed burgers and pasta and designer Ron Arad’s single-piece 3D-printed spectacles – see all 3D printing.

Top photograph by Frank Wojciechowski.

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Post-Tsunami Housing by Shigeru Ban

Japanese architect Shigeru Ban developed these timber and earth houses for the rehabilitation of a Sri Lankan fishing village that was swept away during the 2004 tsunami (+ slideshow).

Post-Tsunami Housing by Shigeru Ban

Developer Phillip Bay asked Shigeru Ban to design a prototype house that could be built cheaply using local materials and would be suitable for the tropical climate. The house was to form a template for the construction of 100 replacement homes in Kirinda.

“This was not going to be a traditional disaster relief effort where we go in and make homes really fast and leave,” said Bay. “I wanted to treat this like a development project.”

Post-Tsunami Housing by Shigeru Ban

Ban’s design comprises a single-storey structure with walls made from compressed earth blocks and a pitched roof made from locally sourced teak and coconut wood.

Each house has two bedrooms, a hall and a sheltered courtyard, which residents can use as a dining room, social space or simply as a place to repair fishing nets.

Post-Tsunami Housing by Shigeru Ban

Adaptable wooden screens divide the rooms, to suit a Muslim lifestyle. “This is the first time I’ve worked for the Muslim societies,” said Ban, “so before I built the houses I had a community meeting to find out what has to be carefully done depending on the generation, for example, we had to separate the man’s space and woman’s space.”

Ban also designed furniture for the residence, using wood from the rubber trees that are common to the region.

Post-Tsunami Housing by Shigeru Ban

The Post-Tsunami Housing was completed in 2007 but was recently named as one of 20 projects on the shortlist for the Aga Khan Award 2013. Other projects on the shortlist include an Islamic cemetery in Austria and a reconstructed refugee camp in Lebanon. Five or six finalists will be revealed later this year and will compete to win the $1 million prize.

Post-Tsunami Housing by Shigeru Ban

Shigeru Ban has also worked on a number of other disaster-relief projects. He devised apartment blocks made from shipping containers for victims of the Japanese earthquake and tsunami of 2011 and was one of several high-profile architects involved in the Make It Right housing project in New Orleans. See more architecture by Shigeru Ban.

Photography is by Dominic Samsoni.

Here’s a project description from the Aga Khan Award organisers:


Post-Tsunami Housing

This project provides 100 houses in a Muslim fishing village, in the region of Tissamaharama, on the southeast coast of Sri Lanka, following the destruction caused by the 2004 tsunami. Shigeru Ban’s aim was to adapt the houses to their climate, to use local labour and materials to bring profit to the region, and to respond to the villagers’ own requirements through direct consultation. For example, kitchens and bathrooms are included within each house, as requested by the villagers, but a central covered area separates them from the living accommodation, as stipulated by the government. The covered area also provides an entertainment space from which women can retreat to maintain privacy. Local rubber-tree wood was used for partitions and fittings, and compressed earth blocks for walls.

Post-Tsunami Housing by Shigeru Ban
Site plan – click for larger image

Location: Kirinda, Sri Lanka (Asia)
Architect: Shigeru Ban Architects, Tokyo, Japan
Client: Philip Bay
Completed: 2007
Design: 2005
Site size: 71 m2 for each house – Total site area: 3’195 m²

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Tucson Mountain Retreat by DUST

This holiday house with rammed earth walls by US architects DUST is nestled amongst the rocky outcrops and sprouting cacti of the Sonoran Desert in Arizona (+ slideshow).

Tucson Mountain Retreat by DUST

With a long narrow body that ambles gently across the terrain, the Tucson Mountain Retreat is a single-storey residence with terraces along its north and south elevations and a small deck upon its roof.

Tucson Mountain Retreat by DUST

DUST architects Cade Hayes and Jesus Robles planned a location away from animal migration paths and overexposure to sunlight and wind, then used local soil to build the house’s red earth walls.

Tucson Mountain Retreat by DUST

“Great effort was invested to minimise the physical impact of the home in such a fragile environment, while at the same time attempting to create a place that would serve as a backdrop to life and strengthen the sacred connections to the awe-inspiring mystical landscape,” explains Hayes.

Tucson Mountain Retreat by DUST

The rooms of the house are separated into three zones, comprising a sleeping and bathing area, a central living room and a music studio. Residents have to leave the building to move between zones, intended to provide acoustic separation.

Tucson Mountain Retreat by DUST

The living room features glazed walls on both sides, which slide open to enable cross ventilation. The music room opens out to a north-facing deck, while the two bedrooms have a terrace along their southern edge and feature a chunky concrete canopy to shelter them from harsh midday sun.

Tucson Mountain Retreat by DUST

A spiralling metal staircase leads up to the roof, offering residents a wide-stretching view of the surrounding desert landscape.

Tucson Mountain Retreat by DUST

The house produces all its own water using a large rainwater harvesting system that filters the liquid until it is clean enough to drink.

Tucson Mountain Retreat by DUST

There’s also a small car parking area a short distance away and it can be accessed via a narrow footpath.

Tucson Mountain Retreat by DUST

Another project we’ve featured from the Arizona deserts is a cast concrete house that is sunken into the ground. We’ve also published a cabin built by students in the Utah desert. See more houses in the US.

Tucson Mountain Retreat by DUST

See more architecture using rammed earth, including a research complex in India.

Photography is by Jeff Goldberg/ESTO.

Here’s a project description from DUST:


The Tucson Mountain Retreat is located within the Sonoran Desert; an extremely lush, exposed, arid expanse of land that emits a sense of stillness and permanency, and holds mysteries of magical proportions. The home is carefully sited in response to the adjacent arroyos, rock out-croppings, ancient cacti, animal migration paths, air movement, sun exposure and views. Great effort was invested to minimise the physical impact of the home in such a fragile environment, while at the same time attempting to create a place that would serve as a backdrop to life and strengthen the sacred connections to the awe-inspiring mystical landscape.

Tucson Mountain Retreat by DUST
Ground floor and roof terrace plan – click for larger image

Intentionally isolating the parking over 400 feet from the house, one must traverse and engage the desert by walking along a narrow footpath toward the house, passing through a dense clustered area of cacti and Palo Verde that obscure direct views of the home. Upon each progressive footstep, the house slowly reveals itself, rising out of the ground. The entry sequence, a series of playfully engaging concrete steps, dissolves into the desert. As one ascends, each step offers an alternative decision and a new adventure. Through this process, movement slows and senses are stimulated, leaving the rush of city life behind.

The home is primarily made of rammed earth, a material that uses widely available soil, provides desirable thermal mass and has virtually no adverse environmental side effects. Historically vernacular to arid regions, it fits well within the Sonoran Desert, while at the same time it embodies inherent poetic qualities that engage the visual, tactile and auditory senses of all who experience it.

The program of the home is divided into three distinct and isolated zones; living, sleeping, and music recording/home entertainment. Each zone must be accessed by leaving the occupied zone, stepping outside, and entering a different space. This separation resolves the clients’ desired acoustic separation while at the same time, offers a unique opportunity to continuously experience the raw desert landscape.

Tucson Mountain Retreat by DUST
Cross section – click for larger image

Rooted in the desert, where water is always scarce, the design incorporates a generous 30,000 gallon rainwater harvesting system with an advanced filtration system that makes our most precious resource available for all household uses.

Solar heat gain is reduced by orienting the house in a linear fashion along an east–west axis, and by minimising door and window openings in the narrow east and west facades. The main living and the sleeping spaces extend into patios and open toward the south under deep overhangs that allow unadulterated views and access to the Sonoran Desert. The overhangs provide shelter from the summer sun while allowing winter sunlight to enter and passively heat the floors and walls. They also scoop prevailing southerly breezes and enhance cross ventilation, which can be flexibly controlled by adjusting the floor-to-ceiling sliding glass doors. When the large glass doors are fully opened, the house is transformed, evoking a boundless ramada-like spirit where the desert and home become one.

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Catch Chair by Jaime Hayón for &tradition

Milan 2013: Spanish designer Jaime Hayón has created a chair with armrests that stretch outwards like limbs for Danish brand &tradition.

Catch Chair by Jaime Hayón for &tradition

Jaime Hayón based the form of the Catch chair on the image of a human figure with outstretched arms.

Catch Chair by Jaime Hayón for &tradition

“When I was drawing Catch, I drew a man with open arms, like a chair that wants to catch you. And it works like that,” explains Hayón.

Catch Chair by Jaime Hayón for &tradition

Produced by furniture brand &tradition, the chair is composed of a moulded polyurethane-foam shell, which is covered in cold cure foam and then finished with either leather or textile upholstery.

Catch Chair by Jaime Hayón for &tradition

The legs are available in white-oiled or black-stained oak, while the upholstery comes in various finishes, from a naked shell to pigmented leather or wool in a broad range of colours.

Catch Chair by Jaime Hayón for &tradition

The chair was presented at the Salone Internazionale del Mobile in Milan last month.

Catch Chair by Jaime Hayón for &tradition

Hayón also unveiled a wingback armchair called Ro and a series of aluminium and terracotta outdoor furniture in Milan.

Catch Chair by Jaime Hayón for &tradition

See more design by Jaime Hayón »
See all our stories about chair design »
See all our coverage of Milan 2013 »

Catch Chair by Jaime Hayón for &tradition

Here’s some more information from &tradition:


Renowned for his whimsical drawings, CATCH is capturing Hayon’s playfulness, while creating a comfortable, upholstered chair with a very light touch. The armrests extend from the padded backrest like literal limbs, ready to embrace you as you sit down. The wooden legs in stained or white-oiled oak adds a grace and lightness to the chair.

Catch Chair by Jaime Hayón for &tradition

“Our collaboration with Jaime Hayon dates back to when the company was founded in 2010,” says brand director martin Kornbek Hansen. But this is the first product to come out of the exchange between Hayon and &tradition, that started over a steak dinner. “It’s a curious relationship,” says Hayon of the collaboration with &tradition, “because I come from a very different ambience. I’ve always liked scandinavian design, but I never knew I’d end up designing for great companies in the north.” The meeting of Hayon’s mediterranean aesthetic with the heritage of the scandinavian craftsmanship has given rise to an innovative form. “It has been interesting to see how Hayon interprets and adapts his design to this tradition,” says Kornbek Hansen.

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Reconstruction of Nahr el-Bared Refugee Camp

The homes of 27,000 Palestinian refugees will be replaced as part of this reconstruction project underway at Nahr el-Bared, 16 kilometres outside of Tripoli, Lebanon (+ slideshow).

Reconstruction of Nahr el-Bared Refugee Camp

First established in the 1940s to accommodate refugees from the Lake Huleh area of northern Palestine, the 19-hectare Nahr el-Bared refugee camp was almost entirely destroyed during the 2007 conflict between the Lebanese Armed Forces and the extremist group Fatah Al-Islam. Thousands of families were forced to abandon their homes and seek temporary refuge at another nearby camp.

Reconstruction of Nahr el-Bared Refugee Camp

In 2008 the United Nations Relief & Works Agency embarked on an ambitious project to replace the buildings that had been destroyed. Working alongside the community-based Nahr el-Bared Reconstruction Commission, the team developed an eight-phase masterplan for 5000 houses, 1500 shops and six school complexes.

Reconstruction of Nahr el-Bared Refugee Camp

The reconstruction includes the replacement of all infrastructure for the camp, including water and sewage networks as well as electricity.

Reconstruction of Nahr el-Bared Refugee Camp

The agency has also been able to increase the amount of public space around the buildings from 11 to 35 per cent by introducing a system of independent structures that can be extended up to four storeys.

Reconstruction of Nahr el-Bared Refugee Camp
Nahr el-Bared before reconstruction

The first families began returning to their homes in 2011 and the first three completed schools opened to students later the same year.

Reconstruction of Nahr el-Bared Refugee Camp

The Nahr el-Bared reconstruction is one of 20 projects on the shortlist for the Aga Khan Award 2013. Five or six finalists will be revealed later this year and will compete to win the $1 million prize. Other projects on the shortlist include an Islamic cemetery in Austria and a museum of paper in China.

Here’s a short project description from the Aga Khan Award organisers:


Reconstructing a camp of 27,000 refugees which was 95% destroyed during the 2007 war involved a planning effort with the entire community, followed by a series of eight construction phases. Limited land and the exigency of recreating physical and social fabrics were primary considerations. Established in 1948, the camp followed the extended-family pattern and building typology of the refugees’ villages. In a layout where roads provided light and ventilation, the goal was to increase non-built areas from 11% to 35%. It was achieved by giving each building an independent structural system allowing for vertical expansion up to four floors on a reduced footprint.

Reconstruction of Nahr el-Bared Refugee Camp
Massing model

Location: Tripoli, Lebanon (West Asia)
Architect: United Nations Relief & Works Agency (UNRWA), Nahr el-Bared Reconstruction Commission for Civil Action and Studies (NBRC)
Client: United Nations Relief & Works Agency (UNRWA), Beirut, Lebanon
Completed: 2011
Design: 2008
Site size: 190,000 sqm

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“Printed human tissues are ten years away”

"Printed human tissues are ten years away"

Michael Renard, executive vice president of bioprinting company Organovo, explains how 3D printing could one day be used to produce replacement tissue, vessels and organs in this interview conducted for our print-on-demand magazine Print Shift (+ transcript).

In the interview Renard describes how Organovo is applying 3D printing to cell biology and tissue engineering.

“We’re working with small pieces of tissue at the moment – a small piece of blood vessel or liver,” he says. “Once you have the cells ready, we can print something in a few hours.”

He also discusses how the technology can be used for experimental drug testing: “Being able to provide functional living human tissues will provide drug-discovery scientists with entirely new means to test drug candidates.”

Although supplemental tissues such as patches to assist heart conditions may reach the clinic soon, he thinks that use of “more advanced replacement tissues will most likely be in 20 years or more.”

The interview forms part of a feature on the way 3D printing is transforming the healthcare industry in Print Shift, our one-off, print-on-demand magazine about this emerging technology.

The magazine was created by the Dezeen editorial team and produced with print-on-demand publisher Blurb. For more information about Print Shift and to see additional content, visit www.dezeen.com/printshift.

Top image: cross-section of bioprinted human liver tissue.

Here’s an edited transcript of the interview, conducted by Claire Barrett:


Claire Barrett: Tell me how Organovo’s 3D printing research began?

Michael Renard: The concept for printing tissues came out of Professor Gabor Forgac’s research at the University of Missouri, enabled through a $5 million grant from the National Science Foundation. That work was about using living cells and depositing cells in an architecture that could create tissue.

It led to the creation of Organovo as a company, which acquired that intellectual property exclusively. Gabor worked mostly with non-human cell sources to build structures, layer by layer. Through that science we arrived where we are today.

Claire Barrett: Is it possible to print an organ?

Michael Renard: Bioprinting should be thought of as the first step in building fully functional tissue. The printing starts a process to create a continuous piece of tissue. That early tissue construct is moved to a bioreactor where it grows and differentiates into its final form. We’re the only company doing it. Our approach is consistent with other forms 3D printing because it’s an additive process, but what is unique to Organovo is our application of the process in the field of cell biology and tissue engineering.

Claire Barrett: How does it work?

Michael Renard: Tissues are built layer by layer, using a combination of hydrogel and cell aggregates deposited in specific spatial arrangements that are programmed into the bioprinter. A wide variety of shapes and orientations can be created using the combination of these materials.

When you deposit cells they have to be the right cells and in the right biological state; the hydrogel holds them in the right place. Then the cells fuse, form junctions, and the hydrogel can be removed to yield a tangible piece of material made up entirely of human cells.

Claire Barrett: How long does it take?

Michael Renard: It all depends what you’re trying to grow. We’re working with small pieces of tissue at the moment – a small piece of blood vessel or liver, for example, so our time from printing to maturity of the tissue can be quite quick. Once you have the cells ready, we can print something in a few hours. It will then take a few days for it to fuse and become anatomically correct, and begin to exhibit expected metabolic properties.

It is unknown how long it will take to build larger, organ-sized tissues. We are researching ways to grow a vascular system as part of the tissue design; that is needed to feed tissue grown on a large scale, without which cell death will occur as tissues expand in size.

Claire Barrett: Are certain tissues easier to grow?

Michael Renard: Virtually all tissues have a specific design and repeating patterns. Each tissue has a consistent set of characteristics, such as certain cell types that create capillary systems, nerves and collagens. These patterns and symmetry can help as the scientific advances and discoveries with one tissue will better inform how to approach the creation of subsequent tissues.

Claire Barrett: How is it used in drug discovery and what are the benefits?

Michael Renard: Being able to provide functional living human tissues will provide drug-discovery scientists with entirely new means to test drug candidates and study their effects in an environment most like that of the drug administered in the human body. This can both improve the safety of potential drugs and help determine whether a drug should be taken forward in very expensive human clinical trials. The end result can be a significant improvement in the efficiency of safety and efficacy testing.

Further to that, diseased tissue models can be built, giving the scientist a completely new approach for understanding disease and disease progression, with the opportunity to find new targets for building drugs with new mechanisms of action.

Claire Barrett: Is the public worried about the ethics of growing organs in a lab?

Michael Renard: People with chronic or degenerative conditions often live with the constant need for medical and assisted-living care. We can keep people alive, but at a cost to the healthcare system and at a reduced quality of life for the patient. What if we could reverse that process, or replace an organ? That’s what the focus is. There is public interest. People are waiting for transplants, but transplant surgeons lack the tissues to help all those in need. Eighteen people die every day in the US waiting for a transplant.

Claire Barrett: What about tissue rejection? Could you take cells from a person in future and grow tissue for transplant and therefore avoid this issue?

Michael Renard: It has become possible to harvest cells from a person’s own body and use them as a source of therapy. Research over the last decade or so shows that many sources of stem cells can be isolated and these often can be a valuable source of potential therapy from the patient themselves. In concept, a tissue engineered from a person’s own DNA should yield a match, with a much-reduced chance of rejection.

Claire Barrett: How far away are you from creating tissue that can be used in operations?

Michael Renard: In the next 10 years it is possible that supplemental tissues, ones that aid in regeneration, will progress through design, clinical and regulatory testing, making it to the clinic as therapies. Examples may include nerve grafts, patches to assist a heart condition, blood vessel segments, or cartilage for a degenerating joint. But more advanced replacement tissues will most likely be in 20 years or more.

Claire Barrett: What needs to happen to enable the next stage of innovation to take place?

Michael Renard: Supplemental tissues need to be shown to be safe, clinically effective and cost-effective in terms of reducing the total cost of care. Also, the ability to grow larger tissues – solving the challenge of creating a vascular and capillary network as an inherent part of the engineering solution – is the critical next step to advance the science.

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